Glucosamine
Jan 2, 2025
Glucosamine
Other names: Brand names: glucosamine and chondroitin, osteo bi-flex advanced.
Mechanism of action:
D-Glucosamine from exogenous sources was shown to incorporate into the metabolic pathway of glycosaminoglycan synthesis. In vitro studies show that glucosamine stimulates the production of proteoglycans and increases the sulfate uptake by articular cartilage.
Common indications/uses:
Osteoarthritis.
Dosing:
Recommended dosage is 500 mg three times daily because of greater experience in clinical trials
Evidence:
Braham et al. [4] did a study and showed that glucosamine supplementation (2000 mg/day, for 12 weeks) may result in decreased pain ratings and self-reported improvements in functional ability of patients with chronic knee pain.
Safety concerns:
One case report discussed a case of asthma being exacerbated by the use of glucosamine supplement for OA, and the physician should keep underlying conditions in mind when discussing supplementation.
Adverse reactions:
Overall adverse effects from glucosamine are minimal, mainly consisting of minor GI symptoms (nausea, vomiting. GI cramps, headache, bloating, dry mouth).
Drug interactions:
No drug interactions were found.
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