Manganese
Feb 16, 2025
Manganese
What is it?
Manganese is a trace mineral that is found in small quantities throughout the body. Magnesium is mostly found in bones and the main vital organs (kidneys, pancreas, and liver) [25].
How does it work in the body?
Manganese plays a role in many bodily functions such as formation (bones, blood clotting factors, sex hormones, connective tissue), metabolism (fat, carbohydrates), absorption (calcium), and regulation (blood sugar). It is also imperative for the functioning of the brain and nerves. Lastly, manganese helps in the process of neutralizing free radicals as it is a component of the antioxidant enzyme superoxide dismutase (SOD) [25].
What is it used for?
Manganese can be used as an antiepileptic, help decrease symptoms of osteo-porosis, increase levels of SOD, and decrease PMS symptoms [25].
Evidence for and against:
Osteoporosis: A study showed that Mn can possibly decrease bone loss for post-menopausal women (in conjunction with An, Cu, and Ca) [25].
No significant clinical evidence that manganese can prevent osteoporosis [25]. Arthritis: More research is needed to study the relationship between the production of SOD and manganese supplementation [25].
PMS: One study showed that patients with PMS had lower levels of manganese in their blood [26].
DM: Some studies show that people with diabetes have low levels of Mn [27]. It is unclear if having diabetes lowers Mn, or if low levels in blood allow for the development of diabetes [27].
Epilepsy: Some studies show that people with seizures have low levels of Mn. It is unclear if having seizures lowers Mn, or if low levels in blood allow for the development of seizures [25].
Safety concerns, side effects, and precautions:
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