Ipriflavone
Jan 2, 2025
Ipriflavone
What Is It?
Ipriflavone is a synthetic isoflavone, used to prevent bone resorption, maintain bone density, and manage osteoporosis.
How Does It Work in the Body?
Ipriflavone works by inhibiting calcium-dependent protease throughout the body [49].
What Is It Used for?
There is evidence that ipriflavone (in conjunction with estrogen and/or calcium) may strengthen bones in postmenopausal women with osteoporosis.
Precautions/Side Effects:
Per a systematic review by Hu et al., mild gastrointestinal symptoms were noted. Additionally, a mild decrease in lymphocyte count was observed but resolved with discontinuation of ipriflavone.
Evidence for and Against:
According to Hu et al., ipriflavone significantly increases bone mineral density and has inhibitory effects on bone resorption markers in postmenopausal women with osteopenia or osteoporosis.
Several studies have shown that genistein and ipriflavone have beneficial effects on bone density and are safe in postmenopausal women. This may be considered as a complementary or alternative option in the prevention and treatment of menopause-related osteoporosis.
Dosage:
Osteoporosis: 200 mg of ipriflavone by mouth, three times daily.
Paget disease: 600–1200 mg of ipriflavone by mouth, daily.
Interactions:
Ipriflavone is contraindicated in individuals with an existing history of hypersensitivity to any of its ingredients (Ipriflavone, Hypromellose, Leucine, or Magnesium Citrate).
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